Sargassum swartzii extracts ameliorate memory functions by neurochemical modulation in a rat model

Food Science and Biotechnology - Recently, considerable attention has been paid to drug exploration from natural sources for treating memory loss, a major manifestation of various neurodegenerative...     

Network Pharmacology Study on Morus alba L. Leaves: Pivotal Functions of Bioactives on RAS Signaling Pathway and Its Associated Target Proteins against Gout

M. alba L. is a valuable nutraceutical plant rich in potential bioactive compounds with promising anti-gouty arthritis. Here, we have explored bioactives, signaling pathways, and key proteins underlying the anti-gout activity of M. alba L. leaves for the first-time utilizing network pharmacology. Bioactives in M. alba L. leaves were detected through GC-MS (Gas Chromatography-Mass Spectrum) analysis and filtered by Lipinski’s rule. Target proteins connected to the filtered compounds and gout were selected from public databases. The overlapping target proteins between bioactives-interacted target proteins and gout-targeted proteins were identified using a Venn diagram. Bioactives-Proteins interactive networking for gout was analyzed to identify potential ligand-target and visualized the rich factor on the R package via the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway on STRING. Finally, a molecular docking test (MDT) between bioactives and target proteins was analyzed via AutoDock Vina. Gene Set Enrichment Analysis (GSEA) demonstrated that mechanisms of M. alba L. leaves against gout were connected to 17 signaling pathways on 26 compounds. AKT1 (AKT Serine/Threonine Kinase 1), γ-Tocopherol, and RAS signaling pathway were selected as a hub target, a key bioactive, and a hub signaling pathway, respectively. Furthermore, three main compounds (γ-Tocopherol, 4-Dehydroxy-N-(4,5-methylenedioxy-2-nitrobenzylidene) tyramine, and Lanosterol acetate) and three key target proteins—AKT1, PRKCA, and PLA2G2A associated with the RAS signaling pathway were noted for their highest affinity on MDT. The identified three key bioactives in M. alba L. leaves might contribute to recovering gouty condition by inactivating the RAS signaling pathway.     

A survey on trust based detection and isolation of malicious nodes in ad-hoc and sensor networks

Mobile ad-hoc networks (MANETs) and wireless sensor networks (WSNs) have gained remarkable appreciation and technological development over the last few years. Despite ease of deployment, tremendous applications and significant advantages, security has always been a challenging issue due to the nature of environments in which nodes operate. Nodes’ physical capture, malicious or selfish behavior cannot be detected by traditional security schemes. Trust and reputation based approaches have gained global recognition in providing additional means of security for decision making in sensor and ad-hoc networks. This paper provides an extensive literature review of trust and reputation based models both in sensor and ad-hoc networks. Based on the mechanism of trust establishment, we categorize the stateof-the-art into two groups namely node-centric trust models and system-centric trust models. Based on trust evidence, initialization, computation, propagation and weight assignments, we evaluate the efficacy of the existing schemes. Finally, we conclude our discussion with identification of some unresolved issues in pursuit of trust and reputation management.     

Sharifa's House

In Bangladesh, a microbanking system exclusively targeted at female ‘entrepeneurs’ has been combined with a streamlined domestic construction process, transforming the possibilities of affordable housing for the rural poor. Dr Adnan Morshed tells Sharifa's story; how a very modest loan from the Grameen Bank allowed Sharifa and her family to build a house and to realise what amounts to very much more than even a permanent home. Copyright © 2007 John Wiley & Sons, Ltd.     

Hydrogen as a renewable and sustainable solution in reducing global fossil fuel consumption

In this paper, hydrogen is considered as a renewable and sustainable solution for reducing global fossil fuel consumption and combating global warming and studied exergetically through a parametric performance analysis. The environmental impact results are then compared with the ones obtained for fossil fuels. In this regard, some exergetic expressions are derived depending primarily upon the exergetic utilization ratios of fossil fuels and hydrogen: the fossil fuel based global waste exergy factor, hydrogen based global exergetic efficiency, fossil fuel based global irreversibility coefficient and hydrogen based global exergetic indicator. These relations incorporate predicted exergetic utilization ratios for hydrogen energy from non-fossil fuel resources such as water, etc., and are used to investigate whether or not exergetic utilization of hydrogen can significantly reduce the fossil fuel based global irreversibility coefficient (ranging from 1 to +∞) indicating the fossil fuel consumption and contribute to increase the hydrogen based global exergetic indicator (ranging from 0 to 1) indicating the hydrogen utilization at a certain ratio of fossil fuel utilization. In order to verify all these exergetic expressions, the actual fossil fuel consumption and production data are taken from the literature. Due to the unavailability of appropriate hydrogen data for analysis, it is assumed that the utilization ratios of hydrogen are ranged between 0 and 1. For the verification of these parameters, the variations of fossil fuel based global irreversibility coefficient and hydrogen based global exergetic indicator as the functions of fossil fuel based global waste exergy factor, hydrogen based global exergetic efficiency and exergetic utilization of hydrogen from non-fossil fuels are analyzed and discussed in detail. Consequently, if exergetic utilization ratio of hydrogen from non-fossil fuel sources at a certain exergetic utilization ratio of fossil fuels increases, the fossil fuel based global irreversibility coefficient will decrease and the hydrogen based global exergetic indicator will increase.     

Melatonin for Neonatal Encephalopathy: From Bench to Bedside

Neonatal encephalopathy is a leading cause of morbidity and mortality worldwide. Although therapeutic hypothermia (HT) is now standard practice in most neonatal intensive care units in high resource settings, some infants still develop long-term adverse neurological sequelae. In low resource settings, HT may not be safe or efficacious. Therefore, additional neuroprotective interventions are urgently needed. Melatonin’s diverse neuroprotective properties include antioxidant, anti-inflammatory, and anti-apoptotic effects. Its strong safety profile and compelling preclinical data suggests that melatonin is a promising agent to improve the outcomes of infants with NE. Over the past decade, the safety and efficacy of melatonin to augment HT has been studied in the neonatal piglet model of perinatal asphyxia. From this model, we have observed that the neuroprotective effects of melatonin are time-critical and dose dependent. Therapeutic melatonin levels are likely to be 15–30 mg/L and for optimal effect, these need to be achieved within the first 2–3 h after birth. This review summarises the neuroprotective properties of melatonin, the key findings from the piglet and other animal studies to date, and the challenges we face to translate melatonin from bench to bedside.     

Sliding mode control of a bioreactor

In this paper, sliding mode control (SMC) of a bioreactor is considered and is compared with PID control. The magnitude of the error in SMC is found to be lower than that in PID control. Moreover, the magnitudes of cells and nutrients were very close to the selected reference values in SMC, whereas they were quite different in PID control. Overall, SMC was more robust against disturbances and had better performance than PID control.     

On a consistent field transfer in non linear inelastic analysis and ultimate load computation

In this work we propose a field transfer operator for remeshing carried out in the course of incremental analysis of a non linear inelastic behavior. The proposed procedure is geared towards the ultimate load computation of a complex structure, where we choose the appropriate mesh grading for each different phase of computations, starting with a coarse mesh for the initial linear response and going towards a more refined mesh for highly nonlinear inelastic response. The proposed projection operator is developed on the basis of diffuse approximation method. The key feature of such an operator is to guarantee the conservation of relevant mechanics quantities which ensures a superior performance of the proposed field transfer with respect to the standard remeshing procedure. We present the illustrative results both for an isotropic damage model and standard plasticity model, indicating very satisfying performance.     

Vector channels for smart antennas. Measurements, statisticalmodeling, and directional properties in outdoor environments

In wireless communications, smart antenna systems that employ antenna arrays coupled with adaptive signal-processing techniques at the basestation improve capacity, coverage, and trunking efficiency. However, design and performance analysis of smart antenna systems strongly depend on channel propagation characteristics of signals present at the antenna array, the so-called vector channels. Here, variation of narrow-band vector channels (spatial signatures) due to a moving terminal is studied in typical suburban settings. Vector channel measurements are taken using a real-time smart antenna system with a uniform circular array at the basestation and a mobile transmitter at several locations. Two different wireless scenarios, namely, pedestrian and car mobile, are implemented to emulate the random movement of the mobile user. In each scenario, the mobile transmitter locations are chosen so that there exists line-of-sight (LOS), nonline-of-sight (NOLOS), or both LOS and NOLOS (mixed) propagation to the basestation. We find that in all cases, the Beta distribution can be used to empirically represent the spatial signature correlations and that large spatial diversity exists in NOLOS cases compared to LOS cases. Also, direction-of-arrivals mostly do not change much with movement in a suburban environment     

Suppression of TRPV1/TRPM8/P2Y Nociceptors by Withametelin via Downregulating MAPK Signaling in Mouse Model of Vincristine-Induced Neuropathic Pain

Vincristine (VCR) is a widely used chemotherapy drug that induced peripheral painful neuropathy. Yet, it still lacks an ideal therapeutic strategy. The transient receptor potential (TRP) channels, purinergic receptor (P2Y), and mitogen-activated protein kinase (MAPK) signaling play a crucial role in the pathogenesis of neuropathic pain. Withametelin (WMT), a potential Phytosteroid isolated from datura innoxa, exhibits remarkable neuroprotective properties. The present investigation was designed to explore the effect of withametelin on VCR-induced neuropathic pain and its underlying molecular mechanism. Initially, the neuroprotective potential of WMT was confirmed against hydrogen peroxide (H₂O₂)-induced PC12 cells. To develop potential candidates for neuropathic pain treatment, a VCR-induced neuropathic pain model was established. Vincristine (75 μg/kg) was administered intraperitoneally (i.p.) for 10 consecutive days (day 1–10) for the induction of neuropathic pain. Gabapentin (GBP) (60 mg/kg, i.p.) and withametelin (0.1 and 1 mg/kg i.p.) treatments were given after the completion of VCR injection on the 11th day up to 21 days. The results revealed that WMT significantly reduced VCR-induced pain hypersensitivity, including mechanical allodynia, cold allodynia, and thermal hyperalgesia. It reversed the VCR-induced histopathological changes in the brain, spinal cord, and sciatic nerve. It inhibited VCR-induced changes in the biochemical composition of the myelin sheath of the sciatic nerve. It markedly downregulated the expression levels of TRPV1 (transient receptor potential vanilloid 1); TRPM8 (Transient receptor potential melastatin 8); and P2Y nociceptors and MAPKs signaling, including ERK (Extracellular Signal-Regulated Kinase), JNK (c-Jun N-terminal kinase), and p-38 in the spinal cord. It suppressed apoptosis by regulating Bax (Bcl2-associated X-protein), Bcl-2 (B-cell-lymphoma-2), and Caspase-3 expression. It considerably attenuated inflammatory cytokines, oxidative stress, and genotoxicity. This study suggests that WMT treatment suppressed vincristine-induced neuropathic pain by targeting the TRPV1/TRPM8/P2Y nociceptors and MAPK signaling.